Protective effect of triphala on radiation induced acute intestinal mucosal damage in Sprague Dawley rats.
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Date
2012-03
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Abstract
Aim of the study was to determine protective effect of triphala on radiation-induced rectal mucosal damage. Male Sprague Dawley rats (30) were divided into 5 groups. Rats in group A were sham irradiated and rats in group B underwent only irradiation. Rats in group C were administered triphala 1g/kg/day orally for 5 consecutive days before irradiation. Rats in group D and E were administered triphala 1 and 1.5 g/kg/day orally for 10 consecutive days, respectively. Rectal mucosal damage was induced by a single fraction of 12.5Gy gamma irradiation (Ir-192) on 5th day. All the rats were autopsied on 11th day and histological changes in surface epithelium, glands, and lamina propria were assessed. Proctitis showed significant improvement in surface epithelium (P<0.024), glands (P<0.000) and lamina propria (P<0.002) in group E compared to group B. Rats in group E showed significantly less change in glands (P<0.000) compared to rats in group D, All histological variables (surface epithelium, P<0.001; glands, P<0.000; lamina propria, P<0.003) compared to rats in group C. In a Tukey-b test, group E had a significantly recovered grade for glands (P<0.000) compared to groups B, C and D. Results of the present study showed that high-dose triphala improved radiation-induced damage of glands.
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Keywords
Epithelium, Glands, Lamina Propria, Proctitis, Radiation Protection, Triphala
Citation
Yoon Won Sup, Kim Chul Yong, Yang Dae Sik, Park Young Je, Park Won, Ahn Yong Chan, Kim Seok-Hyung, Kwon Ghee Young. Protective effect of triphala on radiation induced acute intestinal mucosal damage in Sprague Dawley rats. Indian Journal of Experimental Biology. 2012 Mar; 50(3): 195-200.