Effect of Alternanthera brasiliana (L) Kuntze on healing of dermal burn wound.
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Date
2012-01
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Abstract
Wound healing activity of methanol extract of Alternanthera brasiliana [5% (w/w) ointment] was evaluated in experimental burn wound model in rats. Healing potential was assessed by the rate of wound contraction, estimation of anti-oxidants like catalase, superoxide dismutase, reduced glutathione, protein, vitamin C and hydroxyproline, along with histopathological examination on 8th day post wounding. The statistical data indicated that there was significant increase in wound contraction along with augmented level of antioxidants in granulation tissues in A. brasiliana treated group. Histopathological assessment of the granulation tissue revealed formation of epidermis with keratin layer and deposition of collagen fibers after treatment with the plant extract.
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Keywords
Alternanthera brasiliana, Antioxidants, Collagen, Experimental burn, Wound healing
Citation
Barua Chandana C, Talukdar Archana, Begum Shameem A, Buragohain Bhaben, Roy Jayanti Datta, Pathak Debesh C, Sarma Dilip K, Gupta Asheesh K, Bora Rumi S. Effect of Alternanthera brasiliana (L) Kuntze on healing of dermal burn wound. Indian Journal of Experimental Biology. 2012 Jan; 50(1): 56-60.