Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine.
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Date
2012-01
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Abstract
Anticonvulsant property of Acorus calamus is known. Since combination therapy can lower the dose of individual drug and dose related toxicities, in this study, the effect of co-administration of hydroalcoholic extract of A. calamus (HAEAC) on conventional antiepileptic drugs (AEDs), sodium valproate and carbamazepine was determined using pentylenetetrazole -induced seizures model in rats. On combining the subanticonvulsant doses of HAEAC with sodium valproate and carbamazepine, greater protection as compared to either drug alone was observed. This was not related to change in levels of the AEDs. Thus, the results further substantiate anticonvulsant effect of HAEAC and suggest a potential for add on therapy with AEDs.
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Keywords
Acorus calamus, Carbamazepine, Pentylenetetrazole-induced seizures, Sodium valproate
Citation
Katyal Jatinder, Sarangal Vikas, Gupta Yogendra Kumar. Interaction of hydroalcoholic extract of Acorus calamus Linn. with sodium valproate and carbamazepine. Indian Journal of Experimental Biology. 2012 Jan; 50(1): 51-55.