Stem cell therapies for type 1 diabetes mellitus.
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Date
2011-06
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Abstract
The present review discusses the use of autologous hematopoietic stem cell transplantation (HSCT) for the treatment of diabetes mellitus type 1 (DM 1). It has been observed that high dose immunosuppression followed by HSCT shows better results among other immunotherapeutic treatments for the disease as the patients with adequate beta cell reserve achieve insulin independence. However, this response is not maintained and reoccurrence of the disease is major a major challenge to use HSCT in future to prevent or control relapse of DM 1.
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Keywords
Diabetes mellitus, HSCT, Immunosupression, Stem cell
Citation
Voltarelli Júlio C, Couri Carlos E B, Rodrigues Maria C, Moraes Daniela A, Stracieri Ana-Beatriz P L, Pieroni Fabiano, Navarro George, Leal Angela M O, Simões Belinda P. Stem cell therapies for type 1 diabetes mellitus. Indian Journal of Experimental Biology. 2011 June; 49(6): 395-400.