Helicobacter pylori infection in relation to gastric cancer progression.
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Date
2011-01
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Abstract
Gastric cancer is a major cause of cancer death worldwide, especially in developing countries. The incidence of gastric cancer varies from country to country, probably as a result of genetic, epigenetic, and environmental factors. H. pylori infection is considered as a major risk factor in the development of gastric cancer. However, the scenario varies in Asian countries, exhibiting a higher rate of H. pylori infection and low incidence of gastric cancer, which could be attributed to strain-specific virulence factors and host genetic makeup. In this review, we discuss the various virulence factors expressed by this bacterium and their interaction with the host factors, to influence pathogenesis.
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Keywords
Cytotoxicity associated pathogenicity Island, gastric cancer, H. pylori, ice A gene, vacuolating cytotoxin
Citation
Venkateshwari A, Krishnaveni D, Venugopal S, Shashikumar P, Vidyasagar A, Jyothy A. Helicobacter pylori infection in relation to gastric cancer progression. Indian Journal of Cancer. 2011 Jan-Mar; 48(1): 94-98.