Ligand binding prediction for BRCA1, a key molecule in the pathogensis of breast cancer.
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Date
2010-04
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Abstract
Background : Cell adhesion plays a pivotal role in diverse biological processes that occur in oncogenesis. BRCA1 was the first breast cancer susceptibility gene to be successfully identified and cloned. The role of BRCA1 as a predictive marker of chemotherapy response in breast cancer is proposed. Ligand binding is an important factor in the success of chemoprevention. Materials and Methods : In this work, the author performed a ligand-binding prediction for BRCA1 using a new bioinformatics tool. Results : According to this study, 10 strong possible ligands were identified. Conclusion : These sites can be useful for further drug development studies.
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BRCA1, ligand binding
Citation
Wiwanitkit V. Ligand binding prediction for BRCA1, a key molecule in the pathogensis of breast cancer. Indian Journal of Cancer. 2010 Apr-June; 47(2): 139-141.