Serum copper and zinc levels in mothers and cord blood of their newborn infants with neural tube defects: A case-control study.
Loading...
Date
2009-08
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Objectives: To measure the cord blood and maternal serum levels of folic acid, vitamin B12, zinc, copper, selenium and lead in infants born with neural tube defect (NTD), and to examine a possible relationship between the nutriture of these micronutrients and occurrence of neural tube defect.
Design: Case-control study.
Methods: Maternal serum and cord blood samples were obtained at delivery from 70 healthy mothers and 74 mothers who had a newborn with NTD.
Results: The mean (± SD) maternal serum zinc level in the NTD group was significantly lower than that of the control group (835.6 µg/L ±333.8 µg/L vs. 1035.7 µg/L ± 299.8 µg/L, P=0.004, respectively). The mean maternal and cord serum copper levels in the NTD group were significantly higher when compared to the control group (2831.1 µg/L ± 1017 µg/L vs. 2402 µg/L ± 744.2 µg/L; P=0.03; and 789.8 µg/L vs 517.2 µg/L, P<0.001, respectively). There was a negative correlation between the cord levels of folic acid and copper in the NTD group with the respective maternal serum levels (r=-0.289; P=0.018).
Conclusions: High maternal serum levels of copper and lower level of zinc during pregnancy associated with NTD in newborn.
Description
Keywords
Copper, Folic acid, Micronutrients, Neural tube defects, Zinc
Citation
Zeyrek Dost, Soran Mustafa, Cakmak Alpay, Kocyigit Abdurrahim, Iscan Akin. Serum copper and zinc levels in mothers and cord blood of their newborn infants with neural tube defects: A case-control study. Indian Pediatrics. 2009 Aug; 46(8): 675-680.