Relapse of kala-azar after use of multiple drugs: A case report and brief review of literature.
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Date
2012-04
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Abstract
We present a case of kala-azar infection that recurred in a patient after completion of the standard treatment course of miltefosine, amphotericin B-deoxycholate (short course), and amphotericin B lipid formulations. The patient was cured after continuous amphotericin B-deoxycholate administration for 4 weeks. This is a unique case of relapse following the use of three important drugs. Although amphotericin B-deoxycholate is a second line drug in Nepal, it has shown a satisfactory clinical response with continuous treatment for 4 weeks. Therefore, an extended course of amphotericin B-deoxycholate may be beneficial in patients with resistance to the standard short course and other anti-leishmania drugs.
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Keywords
Amphotericin B, miltefosine, kala-azar
Citation
Pandey K, Pun S B, Pandey B D. Relapse of kala-azar after use of multiple drugs: A case report and brief review of literature. Indian Journal of Medical Microbiology. 2012 Apr-June; 30(2): 227-229.