Therapy of nonalcoholic steatohepatitis (NASH) – antioxidants and cytoprotective agents.
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Date
2011-01
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Abstract
Pathogenesis of nonalcoholic fatty liver disease (NAFLD) and its progressive form
nonalcoholic steatohepatitis (NASH) is not completely understood. Because of the role of
oxidative stress in the pathogenesis, antioxidants and cytoprotective agents have been used
in the treatment of patients with NAFLD/NASH. Various antioxidants and cytoprotective
agents used in these patients include Vitamin E, Vitamin C, Betaine, N- acetyl cysteine, silybin,
lecithin, beta carotene, metadoxine, selenium and ursodeoxycholic acid (UDCA). Most of the
data is available with vitamin E and UDCA, either in isolation or in combination with various
agents. The available data on the use of various agents are either experimental or have small
number of patients and randomized controlled trials with histological efficacy are sparse.
More data is required before any conclusions are drawn regarding the use of anti oxidants
and cytoprotective agents in patients NAFLD/NASH.
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Keywords
Nonalcoholic fatty liver disease, NAFLD, oxidative stress, vitamin E, ursodeoxycholic acid, UDCA
Citation
Duseja Ajay. Therapy of nonalcoholic steatohepatitis (NASH) – antioxidants and cytoprotective agents. Tropical Gastroenterology. 2011 Jan; 32(suppl1): S33-37.