Effect of antioxidant therapy on hospital stayand complications in patients with early acutepancreatitis: A randomised controlled trial.
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Date
2009-10
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Abstract
Background: Oxidative stress (OS) in acute pancreatitis (AP) has been pathologically linked with the systemic inflammatory response and antioxidant supplementation may have a clinical
benefit.
Methods : In this prospective, randomised open label, controlled pilot study, patients admitted
within 72 hours of onset of pain were randomised to receive either placebo (only standard
medical treatment; SMT) or antioxidants (vitamin C 500 mg, N-acetyl cysteine 200 mg 8
hourly and antoxyl forte 1 capsule hourly with standard medical treatment; SMT+AO) daily,
following informed consent. Patients with co-morbid illness and pregnancy were excluded.
Primary efficacy measures were length of hospital stay and complications whilst secondary
measures were biochemical markers of oxidative stress (thiobarbituric acid reactive
substances [TBARS] and superoxide dismutase [SOD] and total antioxidant capacity [TAC]
and vitamin C) at Days 1, 3 and 7.
Results: Of 53 patients, 30 patients were randomised to SMT and 23 patients to SMT+AO.
The mean duration of hospital stay in the SMT group (10.3±7 days) was more compared to
SMT+AOT (7.2±5 days), but was not statistically significant (p=0.07), complications were
similar in the 2 groups. At Day 7, OS was significantly lower in the SMT+AO group when
compared with the SMT group (TBARS, p=0.05; SOD, p=0.03) with a significant increase in
FRAP and vitamin C (p=0.01).
Conclusions: Antioxidant supplementation may decrease the length of hospital stay and
complication rate in patients with AP, but a larger clinical trial is needed to support this
hypothesis. Further, it decreased the OS and improved the antioxidant status in patients with AP.
Description
Keywords
acute pancreatitis, antioxidant supplementation, clinical benefit
Citation
Sateesh Javvaji, Bhardwaj Payal, Singh Namrata, Saraya Anoop. Effect of antioxidant therapy on hospital stayand complications in patients with early acutepancreatitis: A randomised controlled trial. Tropical Gastroenterology. 2009 Oct-Dec; 30(4): 201-206.