Non-familial paediatric colorectal cancers - an 18 years’ experience.
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Date
2009-01
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Abstract
Background: Primary gastrointestinal malignancies constitute only 1% of all paediatric neoplasms.
Aim: The aim of this study was to describe our 18 years’ experience with non-familial
paediatric colorectal malignancies, outlining pertinent features of diagnosis, treatment and
outcome.
Methods: 9 patients of non-familial paediatric colorectal malignancies were admitted in
PGIMS, Rohtak, Haryana between 1990 and 2008. After the initial surgical management, the
advanced cases underwent chemotherapy and radiation therapy where required and were
followed up.
Results: There were six male and three female patients (age range: 7 to 16 years). Three
tumours arose in the rectum, three in the sigmoid colon, one each in the splenic flexure and
appendix, and there was one case of diffuse colonic polyposis. All cases presented with
obstruction and rectal bleeding. Two cases of sigmoid carcinoma were unresectable and
expired 4 months post-surgery. The rest responded to radical resection. Three patients
required palliative radiation therapy. Due to the advanced stage, chemotherapy was given to
all the carcinoma patients. One patient had local recurrence after 5 months and another
developed distant metastasis. The rest are on follow-up and clinically and radiologically
disease free.
Conclusion: Paediatric colorectal malignancy is a rare entity, usually diagnosed in the later
stages, culminating in advanced disease. A majority of cases undergo radical resection due
to the advanced stage of presentation. Advanced stages may also require chemotherapy
and radiation therapy.
Description
Keywords
paediatric colorectal cancer, sigmoid carcinoma, colonic polyposis
Citation
Nair Vimoj, Rattan Kamal Nayan, Kaushal Vivek, Atri Rajeev, Dhankar Rakesh, Kaur Paramjeet, Kadian Joginder. Non-familial paediatric colorectal cancers - an 18 years’ experience. Tropical Gastroenterology. 2009 Jan-Mar; 30(1): 51-53.