Childhood lupus: Experience from eastern India.
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Date
2010-08
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Abstract
Objective. To delineate the clinical behavior of SLE in children from Eastern India and to the differences in disease pattern.
Methods. In the present study, all 44 patients of pediatric SLE who were diagnosed over a period of 5 years in our pediatric
rheumatology clinic were followed prospectively. The resultant database was analyzed using standard statistical methods.
Results. About 3.9% of all rheumatology cases dealt with in the clinic in the last five yrs (n=1063) were SLE. The number of
children in 5-8 yrs and 8-12 yrs age groups were 13 and 27, respectively. The overall female (n=35) to male (n=9) ratio in
this study was 3.8:1. Renal, hematological and Neuropsychiatric features were most common major organ
manifestations(54%,54% and 25% respectively). Joints and skin were the most common minor organs involved. Two case
were ANA negative SLE. Among the typical features of ANA negative disease, only nephritis was found in these patients. Anti
dsDNA was positive in 50 % cases (n=21). C3 levels were studied in all cases with nephritis (n=22) and 68 % (n=15) had
hypocomplementemia. Anti Ro and anti La antibodies were positive in two cases of neonatal lupus. APLA, Anti Sm antibody
and anti U1RNP were negative in the cases where testing was done.
Conclusions. This study has tried to delineate the disease trends of childhood lupus from Eastern India. Certain important
trends have emerged which are different from other contemporary Indian and International observations.
Description
Keywords
Childhood lupus, SLE
Citation
Mondal Rakesh, Nandi Madhumita, Ganguli Suhas, Ghosh Alokendu, Hazra Avijit. Childhood lupus: Experience from eastern India. Indian Journal of Pediatrics. 2010 Aug; 77(8): 889-891.