Congenital langerhans cell histiocytosis with skin and lung involvement: Spontaneous regression.
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Date
2010-07
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Abstract
Congenital self-healing Langerhans cell histiocytosis (CSHLCH) is a rare type of Langerhans Cell Histiocytosis, presenting
at birth or during the neonatal period with eruption of multiple, discrete red-brown papules or nodules that undergo
spontaneous regression. Systemic signs are generally absent. We describe a 4-month-old infant presenting with reddish brown
nodular cutaneous lesions since birth with a past history suggestive of pulmonary involvement. Skin biopsy showed a dermal
infiltrate of pleomorphic histiocytes; which were CD1a and S-100 positive, consistent with the diagnosis of CSHLCH. Both
pulmonary and cutaneous lesions showed spontaneous resolution.
Description
Keywords
Histiocytosis, Congenital, Pulmonary, Skin
Citation
Aggarwal Varun, Seth Anju, Jain Manjula, Krishnamurthy Sriram, Chandra Varkha, Aneja Satinder. Congenital langerhans cell histiocytosis with skin and lung involvement: Spontaneous regression. Indian Journal of Pediatrics. 2010 July; 77(7): 811-812.