Complement components (C3, C4) as Inflammatory markers in asthma.
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Date
2010-07
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Abstract
Objective. To assess the serum levels of complement factors C3 and C4 in Egyptian asthmatic children.
Methods. This case-controlled study comprised of 60 Egyptian children with the diagnosis of bronchial asthma (not in acute
attack) and 60 age-and sex-matched healthy controls. All candidates were subjected to a thorough clinical study, complete
blood counts, absolute eosinophil count and serum complements (C3, C4).
Results. Serum C3 was significantly higher in asthmatics when compared to controls (140.60 ± 38.80 mg/dl vs 107.70 ± 45.00
mg/dl respectively, (p = 0.01). However, differences in serum C4 levels were not significant (41.30±48.80 mg/dl vs 44.60 ±
39.70 mg/dl respectively, p = 0.69). There was a significant positive correlation between severity of asthma and serum C3
(p=0.02) but not with serum C4.
Conclusions. Serum levels of C3 - but not C4 - are elevated in children with stable asthma, with a positive correlation between
serum C3 and severity of asthma.
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Keywords
Asthma, Children, Complement
Citation
Fattah Mohammed Abdel, Baz Mohammed El, Sherif Ashraf, Adel Alia. Complement components (C3, C4) as Inflammatory markers in asthma. Indian Journal of Pediatrics. 2010 July; 77(7): 771-773.