Respiratory syncitial virus in children with acute respiratory infections.
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Date
2010-07
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Abstract
Objective. To study the nutritional status of children with Respiratory Syncitial virus infection.
Methods. One hundred and twenty six children with acute respiratory infection, between the age of 4-24 months, were
investigated for RSV infection with bronchiolitis, pneumonia and upper respiratory tract infection. Nasopharyngeal aspirates
were collected and cytokine responses were determined by ELISA. Upper respiratory tract infections were detected in 16.66%,
bronchiolitis in 30.15% and Pneumonia in 53.17% children.
Results. Of the 126 patients, 46.66% children were positive for RSV while 58.33% were negative for RSV. Children with
bronchiolitis were more commonly positive for RSV compared to URTI and pneumonia. RSV was almost equally distributed
among boys (42.5%) and girls (48.7%). More children were RSV positive when the mean age lesser (8.4 mo) was compared
to RSV negative (9.93 mo). Well nourished children and children with normal birth weight had more RSV positives, though
not statistically significant. In a sub sample analysis of cytokines done (n=25), Interleukin-2 and Interleukin-8 levels were higher
in the RSV positive children and these levels declined after 5 days of illness.
Conclusions. RSV is more commonly associated with bronchiolitis in younger infants with normal birth weight or more weight
for age (WFA). Proinflammatory cytokine IL-8 was secreted at high concentrations in the nasopharyngeal aspirate in all the
children.
Description
Keywords
Respiratory syncitial virus (RSV);, Bronchiolitis, Weight for age, Well nourished children, IL-8
Citation
Hemalatha R, Swetha G Krishna, Seshacharyulu M, Radhakrishna K V. Respiratory syncitial virus in children with acute respiratory infections. Indian Journal of Pediatrics. 2010 July; 77(7): 755-758.