Screening children with severe short stature for celiac disease using tissue transglutaminase.
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Date
2010-04
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Abstract
Objective. To determine the prevalence of anti-tissue transglutaminase in children and adolescents with severe short stature
(<-3 SD).
Methods. All children in age group of 1-18 years having height less than -3 SD for their age and sex, were included. For each
child age and sex matched healthy control (height more than -2 SD) was taken. The included subjects (study & control group)
were subjected to anti tissue transglutaminase (tTG) (IgA) antibody assay estimation.
Results. Of the 112 cases, 23 were tTG positive, giving a prevalence of 20.5% for seropositivity among cases of short stature
while all the controls were seronegative for tTG. All the 23 had tTG values above 40 U/ml and 11 had values above 100 U/
ml. On univariate analysis we found that the presence of chronic diarrhea (OR = 2.55, 95%CI - 1.08-5.98), bulky stools (OR
= 3.03, 95%CI - 1.52-6.05), hemoglobin < 7 gm/dl (OR = 3.12, 95%CI - 1.55 - 6.29) and more severe short stature (<-4 SD)
(OR = 0.41, 95%CI - 0.17- 0.95) had significant association with the tTG positivity. On logistic regression analysis in all cases,
hemoglobin < 7gm/dl (OR = 0.090, 95%CI = 0.024-0.342) and bulky stools (OR=0.212, 95%CI = 0.069-0.649) were
significantly associated with tTG positivity.
Conclusion. More than one fifth of all severe short stature are seropositive for tTG and the chances of seropositivity increases if severe anemia and bulky stool are also associated.
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Keywords
Short stature, Celiac, Anti-tissue transglutaminase
Citation
Ahmad Faraz, Alam Seema, Shukla Indu, Sherwani Rana, Ali Syed M. Screening children with severe short stature for celiac disease using tissue transglutaminase. Indian Journal of Pediatrics. 2010 Apr; 77(4): 387-390.