Polydactyly and genes.
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Date
2010-03
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Abstract
Pediatricians deal with cases with the congenital malformations and malformation syndromes interest many of them. A lot
of information about genes involved in development is available now. Genetics of hand development and genes involved in
polydactyly syndromes is discussed in this article as a prototype to know about genetics of malformations: how it is studied
and what is known. Genetic and chromosomal defects are often associated with congenital malformations. Polydactyly is
one of the commonly seen malformations and genetic defects of many malformation syndromes associated with
polydactyly are known. The role of genetic defect in polydactyly syndromes and the correlation between genotypes and
phenotypes is discussed in this review article.
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Keywords
Polydactyly, Genes in polydactyly, Limb development, Genetics, GLI3
Citation
Phadke Shubha R, Sankar V H. Polydactyly and genes. Indian Journal of Pediatrics. 2010 Mar; 77(3): 277-281.