Pheochromocytoma in children and adolescents.
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Date
2009-11
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Abstract
Eleven subjects aged <20 yr with histologically proven pheochromocytoma between 1987 and 2006 were analyzed. Family
history was present in 18%. In 2 patients, pheochromocytoma was part of VHL and in one it was associated with MEN
2. Twenty four hour urine VMA level was elevated in 100% and metanephrine level in 73%. CT/ MRI were showing the
tumor in all. Prazosin extended release tablets (maximum 30 mg/day) were used in 73% and doxazosin (maximum 12
mg/ day) in 27%. Intraoperative BP fluctuations were seen in 27%. All were biochemically cured after surgery.
Preoperative รก blockade with extended release prazosin and doxazosin were effective in controlling perioperative BP
fluctuations. Hence these drugs can be used in children and adolescents without fear of postoperative hypotension.
Description
Keywords
Pheochromocytoma, Prazosin, Doxazosin, Paroxysmal hypertension, Adrenalectomy
Citation
Ganesh H K, Acharya Shrikrishna V, Goerge Joe, Bandgar Tushar R, Menon Padma S, Shah Nalini S. Pheochromocytoma in children and adolescents. Indian Journal of Pediatrics. 2009 Nov; 76(11): 1151-1153.