Pathology in children of HIV women.
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Date
2009-11
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Abstract
Objective. To assess the frequency of perinatal pathology in children exposed to antiretrovirals in perinatal period.
Methods. Retrospective observational cohort study. Data collected among uninfected children born to HIV-infected women
followed up from 1994 to 2006 in a tertiary Hospital. 220 uninfected children were studied. Factors studied included
maternal, obstetrical and pediatric variables.
Results. The most common disorder found among children exposed to antiretroviral drugs was anemia (84%); 6,4% of
children had neutropenia and more than 24% had thrombocytosis, a finding never described before. Prematurity (24%) and
low birth weight (23.6%) rates were high. Several congenital malformations were found: Poland syndrome, angiomas,
hypospadias, Pierre-Robin sequence, trisomy 8, craniostosis and others. Long-term follow-up revealed neurological,
cardiological and ophthalmological pathologies.
Conclusion. Some pathologies are frequent among children exposed to antiretroviral agents during perinatal life. It is crucial
to carry out long-term studies to assess the safety of this therapy.
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Keywords
AIDS, Pregnancy, Antiretroviral treatment, Adverse effects, Perinatal pathology
Citation
Nso A P, García-Bermejo C, Larru B, Madero R, Muñoz Fernández M A, de José M I. Pathology in children of HIV women. Indian Journal of Pediatrics. 2009 Nov; 76(11): 1125-1130.