Reactive haemophagocytic lymphohistiocytosis.
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Date
2009-06
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Abstract
We present a series of five cases diagnosed and treated as reactive haemophagocytic lymphohistiocytosis (HLH) in three
tertiary referral centers of Kolkata, within a time frame of 3 months. The initial presentations were very variable, the most
prominent clinical feature being - acute renal failure in the first patient, convulsions in the second, encephalopathy the third,
marked cervical lymphadenopathy in the fourth and polyserositis in the fifth. All had a history of prolonged fever preceding
admission and hepatosplenomegaly on examination. Investigations revealed multi-organ involvement with pancytopenia;-
haemophagocytosis was eventually diagnosed by bone marrow examination. These cases highlight the diagnostic
challenge posed by infection associated haemophagocytosis and the need for maintaining a high index of suspicion to
promptly diagnose and treat this potentially life threatening condition.
Description
Keywords
Hemophagocytic lymphohistiocytosis, Pancytopenia, Sepsis
Citation
Pramanik Shanto, Pal Priyankar, Das P K, Chakrabarty Subroto, Bhattacharya Arpita, Banerjee Sushmita. Reactive haemophagocytic lymphohistiocytosis. Indian Journal of Pediatrics. 2009 June; 76(6): 643-645.