Transfusion related acute lung injury.
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Date
2009-10
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Abstract
Transfusion related acute lung injury (TRALI) is an uncommon but potentially fatal adverse reaction to transfusion of plasma containing blood components. We describe a case of 10-year-old male child with aplastic anemia, platelet count of 7800/΅l, B positive blood group who developed fever (39.2C), difficulty in breathing and cyanosis within 2 hrs after transfusion of a random platelet concentrate. Despite the best resuscitative efforts, the child died within next 24 hrs. The present case highlights the fact that TRALI should be kept as a differential diagnosis in all patients developing acute respiratory discomfort within 6 hrs of transfusion. Without a 'gold standard' the diagnosis of TRALI relies on a high index of suspicion and on excluding other types of transfusion reactions. Notification to transfusion services is crucial to ensure that a proper investigation is carried out and at-risk donor and recipients can be identified, and risk reduction measures can be adopted.
Description
Keywords
Blood components, lung injury, transfusion
Citation
Sharma Ratti Ram, Bhattacharya Prasun, Thakral Beenu, Saluja Karan, Marwaha Neelam. Transfusion related acute lung injury. Indian Journal of Pathology & Microbiology. 2009 Oct-Dec; 52(4): 561-563.