Endodermal sinus tumor of the vagina in children: A report of two cases.
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Date
2009-07
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Abstract
Malignant tumors of the vagina in infants and children are rare, with primary germ cell tumor (endodermal sinus tumor [EST]) being rarer, which carries a dismal prognosis. This tumor is often clinically mistaken as botryoid rhabdomyosarcoma and, on histopathological examination, is often misdiagnosed as clear cell adenocarcinoma. Two cases of EST of the vagina in infants aged 9 and 17 months are reported. Both the patients presented with bleeding per vagina and clinically and by ultrasonography were diagnosed as sarcoma botryoides. Both were diagnosed as primary yolk sac tumors. The serum alfa fetoprotein (AFP) level was 4325 and 9328 ng/ml, respectively. One patient aged 9 months expired 2 months after receiving chemotherapy. The other, aged 17 months, was given chemotherapy followed by surgery with reduction of the AFP levels.
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Keywords
Germ cell tumors, pediatric, vaginal endodermal sinus tumor
Citation
Gangopadhyay Mimi, Raha Kalpana, Sinha Swapan K, De Anuradha, Bera Pranati, Pati Shyamapada. Endodermal sinus tumor of the vagina in children: A report of two cases. Indian Journal of Pathology & Microbiology. 2009 Jul-Sept; 52(3): 403-404.