Clinical, endoscopic and pathologic spectrum of non-steroidal anti-inflammatory drug-induced colitis.
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Date
2009-07
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Abstract
Non-steroidal anti-inflammatory drugs (NSAIDs) are widely used for treatment of arthritis and many other painful conditions.
These drugs may cause damage not only to the upper
gastrointestinal tract but also to the small and large intestine.
This prospective study aimed to determine the presence of
colonic lesions among 24 patients who were receiving NSAIDs
for more than 3 months, and presented with diarrhea, intractable
abdominal pain, and lower GI bleeding. Colonoscopy
was done and multiple biopsies from different sites in the
colon were obtained. Colonoscopy was normal in 11 (45.8%),
showed inflammation or superficial ulcers in 7 (29.1%) and
solitary or multiple deep ulcers in 6 (25%). Histology showed
erosions in 12 (50%) and lymphocytic colitis in 9 (37.5%);
histology was normal in 4 (16.6%). NSAID-induced colonic damage may have clinically significant sequel.
Description
Keywords
Colitis, NSAID
Citation
Geramizadeh Bita, Taghavi Alireza, Banan Babak. Clinical, endoscopic and pathologic spectrum of non-steroidal anti-inflammatory drug-induced colitis. Indian Journal of Gastroenterology. 2009 Jul-Aug; 28(4): 150-153.