Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians.
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Date
2009-11
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Abstract
Background: Stevens-Johnson Syndrome (SJS) and toxic epidermal necrolysis are severe cutaneous reactions caused by certain drugs, including antiepileptic carbamazepine. A strong association has been reported between human leucocyte antigen (HLA)-B*1502 and carbamazepine-induced SJS in Han Chinese patients. European studies suggested that HLA-B*1502 is not a universal marker but is ethnicity-specific for Asians. Aim: To study the association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients. Methods: Eight individuals who fulfilled the diagnostic criteria of SJS induced by carbamazepine were identified and HLA-B molecular typing was performed. HLA-B genotyping was carried out by polymerase chain reaction using sequence-specific primers. Results: Out of eight patients studied for genotype, six patients were found to have the HLA-B*1502 allele. Conclusion: This study suggests an association between HLA-B*1502 and carbamazepine-induced SJS in Indian patients.
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Keywords
Carbamazepine, HLA-BFNx011502, Hindu, Indian, Stevens-Johnson syndrome
Citation
Mehta Timir Y, Prajapati Laxman M, Mittal Bharti, Joshi Chaitanya G, Sheth Jayesh J, Patel Dinesh B, Dave Dinkar M, Goyal Ramesh K. Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians. Indian Journal of Dermatology, Venereology and Leprology. 2009 Nov-Dec; 75(6): 579-582.