Proliferative and morphologic characterization of buccal mucosal fibroblasts in areca nut chewers: A cell culture study.
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Date
2011-11
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Abstract
Objective: To isolate, culture and characterize fibroblasts from the buccal mucosa of areca nut chewers with and without oral submucous fibrosis (OSF).
Materials and Methods: Primary fibroblast cultures were established by the collagenase disaggregation technique and the phenotypic and growth characteristics were studied.
Results: Cells cultured from OSF showed a statistically significant increase in both the post-mitotic fibroblast subpopulation and the population doubling time when compared with controls.
Conclusion: There was a significant increase in the pro-fibrotic, post-mitotic subpopulation of fibroblasts in areca nut chewers with OSF.
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Keywords
Areca nut, chewers mucosa, culture, fibroblasts, oral submucous fibrosis
Citation
Mathew Deepu George, Skariah K Skariah, Ranganathan Kannan. Proliferative and morphologic characterization of buccal mucosal fibroblasts in areca nut chewers: A cell culture study. Indian Journal of Dental Research. 2011 Nov-Dec; 22(6): 879.