Recombination in human leukocyte antigen region in two Asian Indian families.
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Date
2012-01
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Abstract
BACKGROUND:
Recombination (crossing over) may generate novel haplotypes that can be beneficial to a population against recently introduced pathogens. It may lead to the generation of new alleles.
SETTINGS AND DESIGN:
A prospective study at a tertiary care centre.
AIM:
To report two rare cases of crossing over in HLA region.
MATERIALS AND METHODS:
Tissue-typing was done by sequence specific primers (SSP) for DR locus and by both SSP and serology for Class I which was reconfirmed on fresh samples.
RESULTS:
In one patient crossing over had taken place in the region of A locus resulting in inheritance of A*01 instead of expected A*11. In second family crossing over had taken place in region of DRB1 locus and the sibling inherited DRB1*08 instead of DRB1*10.
CONCLUSIONS:
Possibility of recombination must be considered when interpreting implausible tissue-typing results of families worked up for BMT.
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Keywords
AML, human leukocyte antigen, recombination, sequence specific primers
Citation
Mishra Mahendra N, Sharma Ajay. Recombination in human leukocyte antigen region in two Asian Indian families. Indian Journal of Human Genetics. 2012 Jan; 18(1): 109-111.