CD46 polymorphism: A probable risk factor for recurrent spontaneous abortion in a northern Indian population.
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Date
2010-03
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Abstract
Background. CD46 is a complement regulatory glycoprotein.
Certain polymorphic forms of the CD46 gene have
been associated with recurrent pregnancy loss in the Caucasian
population. We assessed the role of CD46 polymorphism in
recurrent spontaneous abortion in our setting, as this has not
been done on Indian subjects till date.
Methods. Polymerase chain reaction–restriction fragment
length polymorphism (PCR–RFLP) was carried out on 44
samples each from women with recurrent spontaneous abortion
and normal pregnancy. Genotyping of the CD46 gene was
done using 2.5% agarose gel. Statistical analysis was done
using the TFPGA software.
Results. The absence of CD46H*1 homozygosity was
more pronounced in women with recurrent spontaneous
abortion in the Indian population. Of recurrent aborters, 9%
had the H*1/*1 genotype as compared to 30% of normal
pregnant women.
Conclusion. Although our data did not fit the Hardy–
Weinberg equilibrium, this pilot study indicates that further increasing the sample size might clarify whether polymorphism in the first intron of the CD46 gene can be regarded as a risk factor for recurrent spontaneous abortion.
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Zutshi N, Gandhi M, Kaul P. CD46 polymorphism: A probable risk factor for recurrent spontaneous abortion in a northern Indian population. National Medical Journal of India. 2010 Mar-Apr; 23(2): 85-87.