Nephrogenic systemic fibrosis: A review of the new conundrum.
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Date
2009-11
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Abstract
Nephrogenic systemic fibrosis is an idiopathic, sclerosing condition
that occurs only in patients who have impaired renal function.
Although its most conspicuous manifestation is in the skin, the
condition involves multiple organ systems and is potentially
fatal. Its postulated association with gadolinium-based magnetic
resonance contrast agents has attracted attention. The distinctive
clinical features of this entity include a prodromal systemic
inflammatory syndrome followed by a chronic course of fibrosis
that has a predilection for the skin and subcutaneous tissues of
the extremities. The progressive systemic fibrosing process
involves multiple organs and contributes to the morbidity and
the increased mortality. Appropriate preventive action, prompt recognition and timely reporting of cases may enable better management of this condition.
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Goenka Ajit H, Das Chandan J, Sharma Raju. Nephrogenic systemic fibrosis: A review of the new conundrum. National Medical Journal of India. 2009 Nov-Dec; 22(6): 302-306.