Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy.
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Date
2009-01
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Abstract
Background. Inhibition of the formation of advanced
glycation end-products delays the development of diabetic
nephropathy. Puerarin decreases the formation of these
products. We studied the effect of puerarin in a rat model of
diabetic nephropathy.
Methods. Three groups of rats were studied: a control
group, a diabetic group in whom diabetic nephropathy was
induced by intraperitoneal injection of streptozotocin, and a
puerarin group in which diabetic rats were treated with
puerarin. During and after treatment, measurements were
made on the rats’ general status, blood glucose level, blood
urea nitrogen, serum creatinine, creatinine clearance rate and
urinary albumin excretion over 24 hours. The expression of
collagen I and heparan sulphate proteoglycan in the extracellular
matrix of the glomerulus was assessed by immunohistochemistry.
Results. Rats in the puerarin group had a better general
condition than those with diabetes. They also had lower blood
urea nitrogen, serum creatinine and urinary albumin excretion
rate over 24 hours compared with those in the diabetic group.
The creatinine clearance and expression of heparan sulphate
proteoglycan in the kidney also increased significantly in the
puerarin group compared with that in the diabetic group.
Conclusion. Puerarin seems to have certain protective
effects on diabetic nephropathy induced by streptozotocin.
This is caused possibly by regulating the expression of glomerular extracellular matrix.
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Li Qiangxiang, Xiao Yang, Gong Hanren, Shen Daojun, Zhu Feiyue, Wu Qun, Chen Huiling, Zhong Huiju. Effect of puerarin on the expression of extracellular matrix in rats with streptozotocin-induced diabetic nephropathy. National Medical Journal of India. 2009 Jan-Feb; 22(1): 9-12.