Autism and X-linked hypophosphatemia: A possible association.
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Date
2010-01
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Abstract
We herein report the joint occurrence of an autistic disorder (AD) and X-linked hypophosphatemia. X-linked hypophosphatemia (XLH), an X-linked dominant disorder, is the most common of the inherited renal phosphate wasting disorders. Autism is a pervasive developmental disorder that occurs mainly due to genetic causes. In approximately 6-15% of cases, the autistic phenotype is a part of a broader genetic condition called syndromic autism.
Therefore, reports of cases with the joint occurrence of a known genetic syndrome and a diagnosis of ASD by a child psychiatrist are relevant. A joint occurrence does not, however, mean that there is always a causal link between the genetic syndrome and the autistic behavioural phenotype. In this case, there are a number of arguments countering a causal link.
Description
Keywords
Autistic disorder, genetics, Syndromal autism spectrum disorders, X-linked hypophosphatemia
Citation
Joël Vermeersch, Hans Hellemans, Dirk Deboutte. Autism and X-linked hypophosphatemia: A possible association. Indian Journal of Human Genetics. 2010 Jan; 16(1): 36-38.