A new recurring chromosome 13 abnormality in two older patients with de novo acute myeloid leukemia: An Indian experience.
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Date
2009-09
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Abstract
We report here two cases of trisomy 13 in acute myeloid leukemia M1 subtype. short-term unstimulated bone marrow and peripheral blood lymphocyte culture showed 47, XY, +13 in all metaphase plates and trisomy 13 was confirmed with whole chromosome paint probes. Trisomy 13 in AML-M1 is a rare numerical abnormality. This is the first Indian report of sole trisomy 13 in AML-M1. Here, we present two cases of elder male patients, which may constitute a distinct subtype.
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Keywords
Acute myeloid leukemia-M1, recurrent, sole abnormality, trisomy 13
Citation
Trivedi P J, Patel P S, Brahmbhatt M M, Patel B P, Gajjar S B, Dalal E N, Shukla S N, Shah P M, Bakshi S R. A new recurring chromosome 13 abnormality in two older patients with de novo acute myeloid leukemia: An Indian experience. Indian Journal of Human Genetics. 2009 Sept; 15(3): 137-139.