Immune status following measles vaccination in infants and evaluation for the need of revaccination.
No Thumbnail Available
Date
1989-08-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
In this prospective study, immune status of children vaccinated in infancy was determined at age 12-18 months. In 200 children, preimmunization protective measles hemagglutination (HI) antibody titres (greater than or equal to 1:8) were present in 38.5% of children of 6-8 months, the frequency decreased to 17.6 and 14.3% in age groups 9-11 and 12-18 months, respectively followed by an increasing incidence of 52.5% in those more than 18 months of age. Paired measles HI titre was estimated in 56 children, the post vaccination sample was taken at age 12-18 months, 3-9 months after measles vaccination. Most of the children (98.0%), with no detectable antibody titre, had a protective titre. Again a significant number (p less than 0.001) of children aged 12-18 months had protective HI titres compared to non-vaccinated. These findings suggest that when vaccinated at 9-11 months in our country, there is no need for revaccination later.
Description
Keywords
Citation
Dutta AK, Singhal PK, Khare S, Kumari S, Mathur R, Mullick DN. Immune status following measles vaccination in infants and evaluation for the need of revaccination. Indian Pediatrics. 1989 Aug; 26(8): 765-72