Detection of anti-human papillomavirus antibodies in patients with cervical neoplasia and in normal population.
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Date
1998-01
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Abstract
Because of the relative simplicity of specimen collection comparing to HPV-DNA detection from cervical specimens, HPV serology might have a role in screening and prediction of cervical cancer risk. Serprevalences to HPV proteins in Thai population has not been assessed. The prevelences of antibodies to HPV-16 E6,E7 oncoproteins-derived peptides in peptides in patients with cervical intraepithelial neoplasia (CIN) and invasive cervical cancer, and in control group with normal cervical cytology were studied. The selected peptides were previously shown to contain immunodominant epitopes. The seroprevalences of antibodies to the peptides in the control group were 4.7% - 11.5%. The antibody to an E6 peptide (E6 aa 1-23) was found in 75.5% of patients with invasive cervical cancer, associated with cervical neoplasia. Eighty-five percent of patients with invasive cervical cancer and 17% of the control group had antibodies to at least one of the three peptides.
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Keywords
Detection, Anti-human papillomavirus antibodies, Cervical neoplasia
Citation
Siripanyaphinyo Uamporn, Auewarakul Prasert, Laivejpithaya Somsak, Siritantikorn Sontana, Wasi Chantapong. Detection of anti-human papillomavirus antibodies in patients with cervical neoplasia and in normal population. Siriraj Medical Journal, 1998 Jan; 50(1): 74-78.