Stem cell therapy: A novel & futuristic treatment modality for disaster injuries.
Loading...
Date
2012-01
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Stem cell therapy hold the potential to meet the demand for transplant cells/tissues needed for treating
damages resulting from both natural and man-made disasters. Pluripotency makes embryonic stem
cells and induced pluripotent stem cells ideal for use, but their teratogenic character is a major
hindrance. Therapeutic benefits of bone marrow transplantation are well known but characterizing the
potentialities of haematopoietic and mesenchymal cells is essential. Haematopoietic stem cells (HSCs)
have been used for treating both haematopoietic and non-haematopoietic disorders. Ease of isolation, in
vitro expansion, and hypoimmunogenecity have brought mesenchymal stem cells (MSCs) into limelight.
Though differentiation of MSCs into tissue-specific cells has been reported, differentiation-independent
mechanisms seem to play a more significant role in tissue repair which need to be addressed further. The
safety and feasibility of MSCs have been demonstrated in clinical trials, and their use in combination
with HSC for radiation injury treatment seems to have extended benefit. Therefore, using stem cells for
treatment of disaster injuries along with the conventional medical practice would likely accelerate the repair process and improve the quality of life of the victim.
Description
Keywords
Critical injuries, disasters, haematopoietic stem cells, mesenchymal stem cells, stem cell therapy
Citation
Gurudutta G U, Satija Neeraj Kumar, Singh Vimal Kishor, Verma Yogesh Kumar, Gupta Pallavi, Tripathi R P. Stem cell therapy: A novel & futuristic treatment modality for disaster injuries. Indian Journal of Medical Research. 2012 Jan; 135(1): 15-25.