Genetic architecture of HIV-1 genes circulating in north India & their functional implications.
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Date
2011-12
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Abstract
This review presents data on genetic and functional analysis of some of the HIV-1 genes derived from
HIV-1 infected individuals from north India (Delhi, Punjab and Chandigarh). We found evidence of
novel B/C recombinants in HIV-1 LTR region showing relatedness to China/Mynmar with 3 copies of
Nfκb sites; B/C/D mosaic genomes for HIV-1 Vpr and novel B/C Tat. We reported appearance of a
complex recombinant form CRF_02AG of HIV-1 envelope sequences which is predominantly found
in Central/Western Africa. Also one Indian HIV-1 envelope subtype C sequence suggested exclusive
CXCR4 co-receptor usage. This extensive recombination, which is observed in about 10 per cent HIV-1
infected individuals in the Vpr genes, resulted in remarkably altered functions when compared with
prototype subtype B Vpr. The Vpu C was found to be more potent in causing apoptosis when compared
with Vpu B when analyzed for subG1 DNA content. The functional implications of these changes as
well as in other genes of HIV-1 are discussed in detail with possible implications for subtype-specific
pathogenesis highlighted.
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Keywords
HIV-1 genetic variants, HIV-1 recombinants, HIV-1 subtypes, India
Citation
Neogi Ujjwal, Sood Vikas, Ronsard Larence, Singh Jyotsna, Lata Sneh, Ramachandran V G, Das S, Wanchu Ajay, Banerjea Akhil C. Genetic architecture of HIV-1 genes circulating in north India & their functional implications. Indian Journal of Medical Research. 2011 Dec; 134(6): 769-778.