Tissue factor expression of endothelial cell in response to atherosclerotic risk factors.
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Date
2011-01
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Abstract
Objective: To study the effect of serum from patients with atherosclerotic risk factors on the synthesis of endothelial tissue factor.
Methods: Serum from 30 diabetic patients, 30 hyperlipemic patients, 30 smokers and 30 normal serum were incubated with cultured endothelial cells from a human umbilical vein. The tissue factor of endothelial cells was measured using the assay that was developed in house after 24 hours incubation time.
Results: Smokers’ serum can significantly cause the increase in endothelial tissue factor. The mean level of tissue factor induced by smokers’ serum is 1.12 microunits/cell whereas the mean level of tissue factor induced by diabetic serum, hyperlipemic serum and normal serum is 0.4, 0.48 and 0.2 microunit/cell, respectively.
Conclusion: Smoking may increase the risk of thrombosis by increasing the tissue factor production of endothelial cells.
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Keywords
Endothelial cell, tissue factor, risk factors
Citation
Wongtiraporn Weerasak, Luenee Pusadee, Opartkiattikul Nisarat, Wongtiraporn Wanida, Laiwejpithaya Somsak, Sangkarat Suthi, Laiwejpithaya Sujera. Tissue factor expression of endothelial cell in response to atherosclerotic risk factors. Siriraj Medical Journal, 2011 Jan; 63(1): 1-3.