Paraoxonases : Structure, gene polymorphism & role in coronary artery disease.
Loading...
Date
2009-10
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Paraoxonases (PONs) i.e. PON1, PON2, PON3 are basically lactonases. Of these, PON1 in addition
has an efficient esterase activity and can hydrolyze organophosphates. The PONs prevent low density
lipoprotein cholesterol (LDL-C) from peroxidation, thereby preventing atherosclerosis. The PON1 is
exclusively associated with high density lipoprotein cholesterol (HDL-C) and its antioxidant activity is
largely attributed to PON1 located on it. At present, PON1 status i.e. its activity and concentration, is
considered to be more important than polymorphism alone, in prevention of coronary artery disease
(CAD). Its activity has been found to be affected by a number of pharmacological agents, diet and other
factors, thereby becoming a promising target for pharmacological intervention. The PON2 prevents cell
mediated lipid peroxidation. However, little is known about the role of PON3. This review describes the structure, gene polymorphism, and factors affecting the activity of PONs, and their role in prevention of CAD.
Description
Keywords
Atherosclerosis, coronary artery disease, paraoxonases, polymorphism
Citation
Gupta Nidhi, Gill Kirandip, Singh Surjit. Paraoxonases : Structure, gene polymorphism & role in coronary artery disease. Indian Journal of Medical Research. 2009 Oct; 130(4): 361-368.