Cervical cancer prevention & the role of human papillomavirus vaccines in India.
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Date
2009-09
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Abstract
Human papillomavirus (HPV) is a necessary cause of cervical cancer, the leading cause of cancer deaths
among Indian women. Current screening and prevention programs based on cytology have not been
effective in reducing the disease burden. Two vaccines are now available for primary prevention. They
generate neutralizing antibodies to HPV capsid protein. The vaccines have been shown to confer nearly
100 per cent protection against cervical pre-cancers and genital warts caused by HPV types 16/18 in
HPV naïve population with few or no side effects. Though there is some cross-protection, around 30
per cent of cervical cancers will not be prevented by the vaccine. Vaccination and screening, which are complementary and synergistic, now constitute the new paradigm for prevention of this disease.
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Keywords
Cervical cancer, human papillomavirus, prophylactic vaccine, virus-like particle
Citation
Bhatla Neerja, Joseph Elizabeth. Cervical cancer prevention & the role of human papillomavirus vaccines in India. Indian Journal of Medical Research. 2009 Sept; 130(3): 334-340.