The clinical utility of HPV DNA testing in cervical cancer screening strategies.
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Date
2009-09
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Abstract
Cervical cancer continues to be the commonest cause of death among women in developing countries,
largely due to the failure to the inability to sustain effective cytology-based screening programs. While
this burden may come down following implementation of the human papillomavirus (HPV) vaccine,
screening will still be required. HPV DNA testing is a promising new technology for cervical cancer
prevention and is the most reproducible of all cervical cancer screening tests. Presently, the two assays
most widely used for the detection of genital types are the polymerase chain reaction (PCR) and Hybrid
Capture 2 assays (hc2). Rapid, affordable tests are expected to be available soon. HPV DNA testing can
be used in a variety of clinical scenarios that include primary screening in women older than 30 yr; as
an adjunctive test to cytology; in the triage of women with an equivocal cytologic report, e.g., ASC-US;
or for follow-up post-treatment for cervical intraepithelial neoplasia (CIN). HPV DNA testing can also
be performed on self-collected samples, which allows screening in remote areas and also in women who refuse gynecologic examination.
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Keywords
Cervical cancer, cervical intraepithelial neoplasia (CIN), HPV, screening
Citation
Bhatla Neerja, Moda Nidhi. The clinical utility of HPV DNA testing in cervical cancer screening strategies. Indian Journal of Medical Research. 2009 Sept; 130(3): 261-265.