Plasma paraoxonase activity in patients with systemic sclerosis.
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Date
2009-05
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Abstract
Background & objectives: Systemic sclerosis (SSc) is a connective tissue disease characterized vascular
damage and fi brosis. The aim of this study was to investigate the possible relation between systemic
sclerosis and paraoxonase which is an antioxidant enzyme on the HDL.
Methods: Twenty nine patients with SSc and 16 healthy subjects (control group) participated in the study.
Plasma cholesterol levels, anti-centromere antibody (ACA) levels and paraoxonase (PON) activities were
measured.
Results: Lower level of high-density lipoprotein (HDL) cholesterol was observed in ACA negative SSc
patients than in controls. Paraoxonase activity in ACA positive patients was however found to increase
relative to control and ACA negative patient groups.
Interpretation & conclusions: Our fi ndings suggested that low HDL level in ACA negative SSc patients
might be one of the factors leading to some vascular problems, and increased PON activity in ACA
positive SSc group might have some role in the limitation of cutaneous sclerotic process observed in these
patients. However, these preliminary fi ndings need to be confi rmed with a larger sample.
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Keywords
Anti-centromere antibody, paraoxonase activity, systemic sclerosis
Citation
Ergüder I B, Erten Şükran, Devrim Erdinç, Turgay Murat, Durak İlker. Plasma paraoxonase activity in patients with systemic sclerosis. Indian Journal of Medical Research. 2009 May; 129(5): 609-612.