In vitro interference of Hyptis martiusii Benth. & chlorpromazine against an aminoglycoside - resistant Escherichia coli.
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Date
2009-05
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Abstract
The antibacterial and synergistic activity of the ethanol extract from Hyptis martiusii Benth. was assayed
by microdillution. The growth of two isolates of Escherichia coli tested was inhibited by the extract. The
minimum inhibitory and minimum bactericidal concentrations (MIC and MBC) values ranged from 512
and >1024 μg/ml for the E. coli 27 and 1024 and > 1024 μg/ml for the E. coli ATCC8539, respectively.
A synergism between this extract and all aminoglycosides assayed was demonstrated. In the same form
synergism between chlorpromazine and kanamycin, amikacin and tobramycin was observed, indicating
the involvement of an effl ux system. Extracts from H. martiusii could be used as a source of plant derived
natural products with modifying antibiotic activity and these products may interact and affect multidrug
resistance systems (MDR) as efflux pumps.
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Keywords
Aminoglycosides, antibiotic activity, Hyptis martiusii, multidrug resistance, synergism
Citation
Coutinho Henrique D M, Costa José G M, Lima Edeltrudes O, Falcão-Silva Vivyanne S, Siqueira-Júnior José P. In vitro interference of Hyptis martiusii Benth. & chlorpromazine against an aminoglycoside - resistant Escherichia coli. Indian Journal of Medical Research. 2009 May; 129(5): 566-568.