Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management.
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Date
2010-12
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Abstract
Sperm DNA integrity is of vital importance for foetal development and birth of healthy offspring. Oxidative stress and consequent DNA damage are the major cause of decline in semen quality in men with varicocele. A preliminary study was conducted on 11 men with clinical varicocele who also had high levels of reactive oxygen species (ROS), to assess DNA damage in sperms and ROS levels before and after varicocelectomy. Varicocelectomy resulted in rapid (1 month) significant (P<0.001) decline in free radical levels and slow (3-6 months) significant decline in DNA damage levels. Thus men undergoing varicocelectomy should try concieving only 6 months following surgery.
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Keywords
Infertility, oxidative stress, semen, varicocelectomy
Citation
Dada Rima, Shamsi Monis Bilal, Venkatesh Sunderarjan, Gupta Naramada Prasad, Kumar Rajeev. Attenuation of oxidative stress & DNA damage in varicocelectomy: Implications in infertility management. Indian Journal of Medical Research. 2010 Dec; 132(6): 728-730