Tissue engineering for bone regeneration: stem cells and growth factors in biomaterial scaffolds.
Loading...
Date
2007-10
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Bone tissue engineering requires a scaffold conducive to cell attachment and maintenance of cell
function, together with a rich source of osteoprogenitor cells in combination with osteoinductive growth factors.
Bone loss as a result of trauma or disease is an increasingly serious health problem. The requirement for new
bone to replace or restore the function of injured, damaged, or lost bone is a major clinical and socioeconomic
need. Bone defects still represent a major challenge for orthopaedic and reconstructive surgeons.
Objective: This review aims at outlining the role of stem cells and growth factors in scaffolds, focusing on the
use of mesenchymal stem cells and bone morphogenetic proteins as applied to the research and practice of bone
tissue engineering.
Results and conclusion: Bone tissue engineering has been emerging as a valid approach to the current therapies
for bone regeneration. Therefore, tissue engineering offers a number of possible strategies to the generation of
living prosthesis that could integrate with host tissue reducing the need for further surgery or possible implant
failure.
Description
Keywords
Bone regeneration, growth factors, scaffolds, stem cells, tissue engineering
Citation
Asian Biomedicine (Research Reviews and News); Vol. 1 No. 3 Oct 2007; 229-238.