Renoprotective effects of erythropoietin.
Loading...
Date
2007-08
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Background: Accumulating evidences during the past decade suggest that erythropoietin (EPO) may have
many beneficial actions other than on erythropoiesis because many non-hematopoietic cells, including kidney
cells, also express EPO receptors.
Objective: To summarize evidences of the renoprotective effects of EPO and review the possible mechanisms of
renoprotection provided by EPO.
Results: Experimental studies have demonstrated the renoprotective effects of EPO in acute as well as chronic
renal injury models. These renoprotective actions are likely to be mediated by several mechanisms, either directly
or indirectly. However, EPO therapy is also associated with adverse effects.
Conclusion: EPO is potentially a novel renoprotective drug. Clinical use of EPO for renoprotection could not be
beneficial if adverse side effects of EPO have been overcome.
Description
Keywords
Erythropoietin, kidney disease, renoprotection
Citation
Asian Biomedicine (Research Reviews and News); Vol. 1 No. 2 Aug 2007; 139-150.