The critical role of tubulointerstitium in renal disease progression.
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Date
2008-06
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Abstract
Background: Recent works have demonstrated that, regardless of the primary causes, tubulointerstitial (TI)
fibrosis is the major cause of progression of renal failure.
Objective: To summarize the mechanisms of progression and regression of TI damage.
Results: Experimental studies have shown that there are three common processes of progressive TI damage:
injury, inflammation, and fibrosis. Renin angiotensin system (RAS) blocking agents could substantially decrease
these lesions.
Conclusion: The fulcrum of the balance between progression and regression of TI fibrosis remains to be
elucidated but would be related to the activation of RAS.
Description
Keywords
Progression, regression, renal failure, tubulointerstitial fibrosis
Citation
Asian Biomedicine (Research Reviews and News); Vol. 2 No. 3 Jun 2008; 175-188.