Alpha Tocopherol (Vitamin-E) improves renal dysfunction in rats in acrolein-induced nephrotoxicity.
Loading...
Date
2007-01
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
Acrolein, one of the most common environmental and industrial pollutants is mainly formed during the combustion of organic matter. Due to the widespread presence of acrolein (1%-13%) among the total atmospheric aldehydes, and its potential health hazards, the present study was carried out to evaluate the biochemical mechanism of acrolein on oxidative stress-mediated nephrotoxicity. The purpose of this study was to investigate the protective effect of a-tocopherol (a form of Vitamin E), against acrolein-induced nephrotoxicity. Male Wistar rats weighing 90–100 g were used in the study. The rats were divided into three groups: Group I was given distilled water; group II was given acrolein at a concentration of 2.5 mg/kg body weight/day through oral intubation, for a period of 45 days; group III was given an oral dose of acrolein (2.5 mg/kg body weight/day) supplemented with α-tocopherol in the diet at a concentration of 65 mg/kg diet/day. The levels of reduced glutathione, ascorbic acid, α-tocopherol and the activity of catalase were decreased significantly (P<0.001), whereas the activities of superoxide dismutase, glutathione peroxidase (P<0.001) and glutathione-S-transferase (P<0.01) were increased in acrolein-treated rat kidney. The levels of blood urea nitrogen and serum creatinine were increased significantly (P<0.001) in experimental animals, whereas the level of blood glucose was decreased significantly (P<0.001). These results suggest that supplementation of vitamin E effectively scavenges free radicals in tissues, regenerating the antioxidants and the antioxidant enzymes which prevent renal deterioration in acrolein-induced toxicity in rats. It appears that in the case of renal impairment, α-toco-pherol therapy could emerge as an additional therapeutic modality in reducing the damage that often results from certain anti-cancer drugs like cyclophosphamide, where acrolein is one of the toxic metabolites, forming acroleinprotein adducts.
Description
Keywords
Acrolein, Renal Dysfunction, Nephrotoxicity, α-Tocopherol, Antioxidants
Citation
Rengaswamy Gopal. Alpha Tocopherol (Vitamin-E) improves renal dysfunction in rats in acrolein-induced nephrotoxicity. Journal of the Indian Society of Toxicology. 2007 Jan; 3(1): 27-31.