CYTOMEGALOVIRUS-ASSOCIATED ANTERIOR UVEITIS PRESENTING AS FUCHS’ HETEROCHROMIC UVEITIS SYNDROME: A CASE REPORT
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Date
2009-09-21
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Chiang Mai Medical Journal
Abstract
Purpose: To investigate the etiologic organism in an immunocompetent patient with uveitis typical of Fuchs’ heterochromic uveitis syndrome (FHUS) by aqueous humor and vitreous humor analysis.
Design: Case report and review of literature
Method: The aqueous and vitreous fluid samples from a female patient with FUCHs’ heterochromic uveitis syndrome, who consulted the Uveitis Clinic of the Department of Ophthalmology, Maharaj Nakorn Chiang Mai Hospital, Faculty of Medicine, Chiang Mai University, were analyzed for Rubella virus, Cytomegalovirus (CMV), Herpes Simplex Virus-1 (HSV-1), Herpes Simplex Virus-2 (HSV-2), Varicella Zoster Virus (VZV) and Toxoplasma gondii (T. gondii) DNAs by real-time polymerase chain reaction (PCR). Comparison of specific antibody production in ocular fluid and plasma was determined by Goldmann-Witmer coefficient (GWC) analysis. The clinical data, ocular findings and treatment were also reviewed.
Results: Positive CMV DNA and GWC analyses were found in the vitreous fluid. Meanwhile, aqueous fluid examination showed all negative results.
Conclusion: CMV infection was identified in a vitreous sample of an immunocompetent patient with uveitis typical for FHUS.
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Chiang Mai Medical Journal; Vol.48 No.2 June 2009 (pages 43 - 76); 71 - 76