The effect of cobra (Naja naja) venom on blood coagulation/fibrinolysis system and on red blood cells
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1992-08-01
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The effects of cobra (Naja naja) venom on blood coagulation , fibrinolysis and red blood cells were studied in vitro. Cobra venom had dose dependent inhibition effect on both intrinsic and extrinsic coagulation pathways. It also had inhibitive/ destructive effect on the individual clotting factors V, VII and X but on effect on the action of thrombin on fibrinogen. However, cobra venom had neither fibrinolytic nor fibrinogenolytic effect even at high venom concentration (10 mg/ ml). Furthemore, cobra venom had direct haemolytic effect shown by increased red cell fragility and raised plasma haemoglobin level.
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Khin Ei Han, Than Than, Myat Mon Oo, Ni Win. The effect of cobra (Naja naja) venom on blood coagulation/fibrinolysis system and on red blood cells. Myanmar Health Sciences Research Journal. 1992; 4(2): 100-104