Effect of 'Mentat' on the pharmacokinetics of single and multiple doses o phenytoin in rabbits.

No Thumbnail Available
Date
1999-06-13
Authors
Journal Title
Journal ISSN
Volume Title
Publisher
Abstract
The effect of 'Mentat', a herbal preparation, was studied on pharmacokinetics of single and multiple doses of phenytoin in rabbits. No significant effect was found after single oral dose of 'Mentat' on single dose kinetics of phenytoin. However, 'Mentat' administration for 7 days increased the steady state kinetic parameters. Peak plasma phenytoin concentration, area under the implasma concentration and elimination half life were significantly increased and t-max was significantly reduced, indicating the suppression of phenytoin metabolism by 'Mentat'.
Description
Keywords
Citation
Garg SK, Islam AS, Kumar N, Sehgal M, Bhargava VK. Effect of 'Mentat' on the pharmacokinetics of single and multiple doses o phenytoin in rabbits. Neurology India. 1999 Jun; 47(2): 104-7
URI
https://imsear.searo.who.int/handle/123456789/121606
Collections
Neurology India