Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy.
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2003-09-04
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The reading frame hypothesis has been proposed to explain the molecular basis of two allelic forms of muscular dystrophies, Duchenne/Becker muscular dystrophy (D/BMD). To evaluate the hypothesis in Indian D/BMD patients, we analyzed deletion of dystrophin exons in 147 DMD and 19 BMD patients. Our studies showed deviation of more than 30% from the reading frame hypothesis in DMD patients (47/147). The present results implicate a need to reevaluate the reading frame hypothesis.
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Pandey GS, Kesari A, Mukherjee M, Mittal RD, Mittal B. Re-evaluation of reading frame-shift hypothesis in Duchenne and Becker muscular dystrophy. Neurology India. 2003 Sep; 51(3): 367-9